Although the concept of "spiritual health" has become popular in the contemporary era and with the emphasis of the World Health Organization, its roots and foundations have long existed in Islamic spiritual medicine, ethics, and mysticism. The present study, with an anthropological approach and relying on the foundations of practical mysticism, explains what "mystical-based spiritual health" is. In this regard, health is defined as a combination of the two concepts of "assets and abilities" and its carrier is the "true self" or the "heart truth" that has two valleys, the physical and the spiritual, and is equipped with the soldiers of reason and ignorance. The factor that realizes this health is "practical reason" that, by controlling, activating, and coordinating the powers, leads them towards a monotheistic structure. The findings of the study show that the basis for the formation of spiritual health in mysticism is the concept of "spiritual temperament" which is realized in two parts: "mountain" (resulting from the existential combination in the descending arc) and "acquisitive" (resulting from the voluntary combination of beliefs and actions in the ascending arc). Finally, mystic-based spiritual health is: the existential state and dignity of the truth of the heart resulting from the moderation of spiritual temperament (mountain and acquisitive) which provides the ability to naturally and smoothly issue spiritual actions and guides man to self-discovery and lasting divine peace.