Background and Aim: This study was conducted to evaluate the impact of a spiritual health educational program on depression and anxiety among first-period secondary school students. Given the increasing prevalence of mental disorders among adolescents, this research aimed to investigate practical strategies for reducing symptoms of depression and anxiety through strengthening the spiritual dimensions of health.

Methodology: The present study was a quasi-experimental design with a pre-test/post-test and unequal control group. The study population consisted of all first-period secondary school students in Razavi Khorasan Province during the academic year 1403 (2024–2025). Using random cluster sampling, one school was selected, and 30 students with the highest scores on depression and anxiety measures (15 in each group) were randomly assigned to experimental and control groups. The experimental group received spiritual health education over 10 two-hour sessions spanning two months, while the control group received no intervention. Instruments included the Beck Depression Inventory (Beck, 1961) and the Beck Anxiety Inventory (Beck et al., 1988). Data were analyzed using descriptive statistics and analysis of covariance (ANCOVA) with SPSS version 24.

Findings: The results indicated a significant difference between the two groups in depression scores (p < 0.05), demonstrating the positive role of the spiritual health educational program in reducing depressive symptoms. Additionally, a significant difference was observed in anxiety levels between the experimental and control groups (p < 0.05), confirming the effectiveness of this intervention in alleviating anxiety among students.

Conclusion: Spiritual health education significantly reduces depression and anxiety in first-period secondary school students. These findings can serve as a foundation for designing educational programs and psychological interventions in schools.